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9.1. What are the system requirements for Wine?
The rule of thumb is that if your application runs fine in Windows, it should run fine on the same system using Wine. Wine, along with the operating system you use to run it, generally requires less disk space and memory than Windows itself. If you're not currently running a Windows application, Wine won't consume any resources at all other than about 20 megabytes of disk space.
Takže záleží na aplikaci, kterou spouštíš pod wine, pokud běžela na tom PC ve windows poběží i pod wine se stejným vytížení HW prostředků.